Nonlinear pharmacokinetic models for 5-fluorouracil in man: intravenous and intraperitoneal routes.

摘要: A two-compartment physiologic pharmacokinetic model has been developed for 5-fluorouracil (5FU). This model, which incorporates saturable whole body clearance, satisfactorily predicts disappearance kinetics after an intravenous bolus and steady-state levels during constant infusions. half-saturating concentration (KM) of 15 microM was determined by comparison simulations with literature data. Both hepatic extrahepatic elimination can be inferred 5FU, but the exact anatomic or compartmental location clearance cannot from available clinical The effect venous arterial plasma sampling is discussed. extended to include intraperitoneal oral administration 5FU addition peritoneal fluid liver compartments.