Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancer.

作者: M.M Borner , P Schöffski , R de Wit , F Caponigro , G Comella

DOI: 10.1016/S0959-8049(01)00371-9

关键词: CmaxAnesthesiaOral administrationFluorouracilRegimenCrossover studyInternal medicineMedicineBolus (medicine)PharmacokineticsStomatitisGastroenterology

摘要: … Although the pharmacokinetic analyses of our study clearly demonstrate higher peak 5-FU concentrations and AUC values with iv 5-FU/LV, this pharmacokinetic advantage did not …

参考文章(22)
A F Sobrero, C Aschele, J R Bertino, Fluorouracil in colorectal cancer--a tale of two drugs: implications for biochemical modulation. Journal of Clinical Oncology. ,vol. 15, pp. 368- 381 ,(1997) , 10.1200/JCO.1997.15.1.368
M A Poon, M J O'Connell, C G Moertel, H S Wieand, S A Cullinan, L K Everson, J E Krook, J A Mailliard, J A Laurie, L K Tschetter, Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. Journal of Clinical Oncology. ,vol. 7, pp. 1407- 1418 ,(1989) , 10.1200/JCO.1989.7.10.1407
Scot C. Remick, Kendra D. Tutsch, Jean L. Grem, Lavonne M. Nieting, Dona B. Alberti, James K V Willson, James K V Willson, James K V Willson, Joan Bruggink, Paul H. Fischer, Mary B. Tombes, Donald L. Trump, Phase I trial of 5-fluorouracil and dipyridamole administered by seventy-two-hour concurrent continuous infusion. Cancer Research. ,vol. 50, pp. 2667- 2672 ,(1990)
G Liu, E Franssen, M I Fitch, E Warner, Patient preferences for oral versus intravenous palliative chemotherapy. Journal of Clinical Oncology. ,vol. 15, pp. 110- 115 ,(1997) , 10.1200/JCO.1997.15.1.110
Jerry M Collins, Robert L Dedrick, Franklin G King, James L Speyer, Charles E Myers, Nonlinear pharmacokinetic models for 5-fluorouracil in man: intravenous and intraperitoneal routes. Clinical Pharmacology & Therapeutics. ,vol. 28, pp. 235- 246 ,(1980) , 10.1038/CLPT.1980.156
Bruno Reigner, Karen Blesch, Erhard Weidekamm, Clinical Pharmacokinetics of Capecitabine Clinical Pharmacokinectics. ,vol. 40, pp. 85- 104 ,(2001) , 10.2165/00003088-200140020-00002
Alan Coates, Suzanne Abraham, S.B. Kaye, Timothy Sowerbutts, Cheryl Frewin, R.M. Fox, M.H.N. Tattersall, On the receiving end—patient perception of the side-effects of cancer chemotherapy European Journal of Cancer and Clinical Oncology. ,vol. 19, pp. 203- 208 ,(1983) , 10.1016/0277-5379(83)90418-2
James Carmichael, Tadeusz Popiela, David Radstone, Stephen Falk, Markus Borner, Amit Oza, Torben Skovsgaard, Stephane Munier, Christophe Martin, Randomized Comparative Study of Tegafur/Uracil and Oral Leucovorin Versus Parenteral Fluorouracil and Leucovorin in Patients With Previously Untreated Metastatic Colorectal Cancer Journal of Clinical Oncology. ,vol. 20, pp. 3617- 3627 ,(2002) , 10.1200/JCO.2002.10.129
G. J. Peters, J. Lankelma, R. M. Kok, P. Noordhuis, C. J. van Groeningen, C. L. van der Wilt, S. Meyer, H. M. Pinedo, Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma. Cancer Chemotherapy and Pharmacology. ,vol. 31, pp. 269- 276 ,(1993) , 10.1007/BF00685670