Outbreak of jaundice and hemorrhagic fever in the Southeast of Brazil in 2001: detection and molecular characterization of yellow fever virus.
作者： A.M.B. de Filippis , R.M.R. Nogueira , H.G. Schatzmayr , D.S. Tavares , A.V. Jabor
DOI: 10.1002/JMV.10226
关键词: Yellow fever 、 Flavivirus 、 Outbreak 、 Virus 、 Genotype 、 Biology 、 Seroconversion 、 Virology 、 Flaviviridae 、 Molecular epidemiology
摘要: Between January and March 2001, an outbreak of jaundice hemorrhagic fever occurred in the state Minas Gerais, Southeast region Brazil, which a mortality rate 53% was reported. Seroconversion, virus isolation, histopathological immunohistochemical findings, reverse transcription-polymerase chain reaction (RT-PCR) identified yellow (YFV) as etiological agent responsible for outbreak. Partial nucleotide sequence analysis from fragment YFV genome spanning parts nonstructural (NS) 5 gene 3' noncoding (3' UTR) showed that involved this belongs to South American genotype I differs Brazilian 1996.
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