Effect of gelatin sponge with colloid silver on bone healing in infected cranial defects.
作者： Yuliang Dong , Weiqing Liu , Yiling Lei , Tingxi Wu , Shiwen Zhang
DOI: 10.1016/J.MSEC.2016.09.015
关键词: Gelatin sponge 、 Staphylococcus aureus 、 Materials science 、 Pathology 、 Debridement 、 Anatomy 、 Colloid 、 Gelatin 、 Antibacterial agent 、 Antibiotics 、 Bone healing
摘要: Abstract Oral infectious diseases may lead to bone loss, which makes it difficult achieve satisfactory restoration. The rise of multidrug resistant bacteria has put forward severe challenges the use antibiotics. Silver (Ag) long been known as a strong antibacterial agent. In clinic, gelatin sponge with colloid silver is used reduce tooth extraction complication. To investigate how this material affect infected defects, methicillin-resistant Staphylococcus aureus (MRSA) 3-mm-diameter cranial defects were created in adult female Sprague-Dawley rats. One week after infection, debrided all nonviable tissue and then implanted (gelatin/Ag group) or alone (gelatin group). At 2 3 days debridement, significantly lower mRNA expression levels IL-6 TNF-α plate colony count value detected gelatin/Ag group than control. Micro-CT analysis showed significant increase newly formed volume fraction (BV/TV) treated defects. HE stained cranium sections also faster rate defect closure These findings demonstrated that can effectively infection caused by MRSA accelerate healing process.
sci-hub.se 参考文章(55)
M. Sela, Ruth Arnon, Studies on the chemical basis of the antigenicity of proteins. 1. Antigenicity of polypeptidyl gelatins Biochemical Journal. ,vol. 75, pp. 91- 102 ,(1960) , 10.1042/BJ0750091
Avinash Sonawnae, Jena, Mohanty, Mallick, Jacob, Toxicity and antibacterial assessment of chitosan-coated silver nanoparticles on human pathogens and macrophage cells International Journal of Nanomedicine. ,vol. 7, pp. 1805- 1818 ,(2012) , 10.2147/IJN.S28077
A.D. Russell, W.B. Hugo, ANTIMICROBIAL ACTIVITY AND ACTION OF SILVER Progress in Medicinal Chemistry. ,vol. 31, pp. 351- 370 ,(1994) , 10.1016/S0079-6468(08)70024-9
Nadia Silvestry-Rodriguez, Enue E. Sicairos-Ruelas, Charles P. Gerba, Kelly R. Bright, Silver as a disinfectant. Reviews of Environmental Contamination and Toxicology. ,vol. 191, pp. 23- 45 ,(2007) , 10.1007/978-0-387-69163-3_2
Xuefeng Zhao, Tadatoshi Sato, Michael Densmore, Christiane Schüler, Reinhold G Erben, Marc D McKee, Beate Lanske, Quan Yuan, Yan Jiang, Increased osteopontin contributes to inhibition of bone mineralization in FGF23-deficient mice. Journal of Bone and Mineral Research. ,vol. 29, pp. 693- 704 ,(2014) , 10.1002/JBMR.2079
P. D. Bragg, D. J. Rainnie, The effect of silver ions on the respiratory chain of Escherichia coli. Canadian Journal of Microbiology. ,vol. 20, pp. 883- 889 ,(1974) , 10.1139/M74-135
S.G. Giulieri, P. Graber, P.E. Ochsner, W. Zimmerli, Management of infection associated with total hip arthroplasty according to a treatment algorithm. Infection. ,vol. 32, pp. 222- 228 ,(2004) , 10.1007/S15010-004-4020-1
Joana F. da Silva Domingues, Steven Roest, Yi Wang, Henny C. van der Mei, Matthew Libera, Theo G. van Kooten, Henk J. Busscher, Macrophage phagocytic activity toward adhering staphylococci on cationic and patterned hydrogel coatings versus common biomaterials Acta Biomaterialia. ,vol. 18, pp. 1- 8 ,(2015) , 10.1016/J.ACTBIO.2015.02.028
Chang-ying Sun, Yan-jun Che, Shi-jin Lu, Preparation and application of collagen scaffold-encapsulated silver nanoparticles and bone morphogenetic protein 2 for enhancing the repair of infected bone Biotechnology Letters. ,vol. 37, pp. 467- 473 ,(2015) , 10.1007/S10529-014-1698-8
Subhra Jana, Tarasankar Pal, Synthesis, characterization and catalytic application of silver nanoshell coated functionalized polystyrene beads. Journal of Nanoscience and Nanotechnology. ,vol. 7, pp. 2151- 2156 ,(2007) , 10.1166/JNN.2007.785