Non-Antiretroviral Microbicides for HIV Prevention.

摘要: Non-antiretroviral microbicide candidates were previously explored as a female-controlled method of preventing sexual transmission HIV. These products contained non-HIV specific active compounds that ultimately found to disrupt the vaginal epithelium, cause increased immune activation in female genital tract, disturb flora, and/or other irritation precluded their use microbicides. Due failure these first-generation candidates, there was shift focus developing HIV pre-exposure prophylaxis and microbicides containing small-molecule antiretrovirals. Even with limited success antiretroviral-based clinical evaluations no commercially available products, has been significant progress research. The lessons learned from previous trials have given rise more rigorous preclinical evaluation aims be better at predicting efficacy safety novel formulation delivery technologies. advances resulted renewed interest non-antiretroviral-based microbicides, such broadly neutralizing antibodies (for example, VRC01) anti-viral proteins Griffithsin), options for persons not wanting antiretroviral drugs, potential prevent multiple sexually transmitted infections.