Cytotoxic T Lymphocyte Recognition of HLA-G in Mice

摘要: Abstract Several features of HLA-G’s sequence and expression pattern distinguish HLA-G from its classical counterparts. These features, including limited polymorphism at the maternal-fetal interface, have been used as a basis for suggesting distinct functional role this nonclassical class I HLA molecule. On other hand, published data do demonstrate that has much in common with It associates β2-microglobulin cytosolic peptides, it binds to CD8, presence can inhibit NK-cell-mediated lysis HLA-G-bearing target cells. To develop model which function could be more thoroughly studied, we produced several -expressing transgenic mouse strains. We report here results skin graft experiments show nontransgenic mice reject HLA-G-expressing murine foreign rejection is associated recipient lymphocytes capable specifically lysing In addition, are described recognize “self” Together reported stimulating an HLA-G-restricted CTL response, molecules serve lytic interactions CTLs, involved education lymphocytic repertoire mice.