Risk of germ cell testicular cancer according to origin: a migrant cohort study in 1,100,000 Israeli men.

摘要: Testicular cancer incidence is highest among men of northern European ancestry and lowest Asian/African descent. We conducted a large-scale migrant cohort study to assess origin generation as predictors testicular germ cell tumors (TGCTs), controlling for possible confounders. Data on 1,092,373 Jewish Israeli males, who underwent general health examination prior compulsory military service at ages 16-19 between the years 1967-2005, were linked Israel National Cancer Registry obtain incident TGCTs up 2006. Cox proportional hazards was used model time event. Overall, 1,001 cases (534 seminoma 467 nonseminoma) detected during 19.2 million person-years follow-up. Origin strong independent predictor with remarkably low North African-born (HR = 0.10, 95% CI: 0.04-0.21) Asian-born 0.35, 0.20-0.62), while intermediate Israeli-born African 0.48, 0.40-0.58) Asian 0.56, 0.47-0.66), compared origin. A comparison born yielded HR 2.31 (1.36-3.93). Significant risk factors controlled year birth, education height. Findings persisted when analyses stratified by histologic subtypes TGCTs. The findings lower rates in Africa Asia ancestry, but steep increase next migrants, particularly migrants from Africa, provide clues direct further research role modern lifestyle environment etiology