Inhibition of rat fat cell lipolysis by monoamine oxidase and semicarbazide-sensitive amine oxidase substrates.

摘要: It has been demonstrated that amine oxidase substrates stimulate glucose transport in cardiomyocytes and adipocytes, promote adipogenesis pre-adipose cell lines lower blood diabetic rats. These insulin-like effects are dependent on oxidation by semicarbazide-sensitive or monoamine oxidase. The present study aimed to investigate whether also exhibit another property, the inhibition of lipolysis. We therefore tested influence tyramine benzylamine lipolytic activity rat adipocytes. amines did not modify basal lipolysis but dose-dependently counteracted stimulation induced agents. response 10 nM isoprenaline was totally inhibited 1 mM. blockade produced mM glutathione suggested generation oxidative species, which occurs during oxidation, involved antilipolytic effect. Among products resulting from only hydrogen peroxide a manner potentiated vanadate, as for benzylamine. Antilipolytic responses insulin were sensitive wortmannin. data suggest is novel effect mediated generated oxidation.