Preliminary in vivo efficacy studies of a recombinant rhesus anti-α4β7 monoclonal antibody
作者： L.E. Pereira , N. Onlamoon , X. Wang , R. Wang , J. Li
DOI: 10.1016/J.CELLIMM.2009.06.012
关键词: Biology 、 In vivo 、 Monoclonal antibody 、 Immunology 、 Antibody 、 Receptor 、 Simian immunodeficiency virus 、 Recombinant DNA 、 Rhesus macaque 、 Gastrointestinal tract
摘要: Recent findings established that primary targets of HIV/SIV are lymphoid cells within the gastrointestinal (GI) tract. Focus has therefore shifted to T-cells expressing α4β7 integrin which facilitates trafficking GI tract via binding MAdCAM-1. Approaches better understand role α4β7+ in pathogenesis include their depletion or blockade synthesis, and/or homing capabilities vivo. Such studies can ideally be conducted rhesus macaques (RM), non-human primate model AIDS. Characterization expression on cell lineages RM blood and tissues reveal low densities by NK cells, B-cells, naive TEM (effector memory) T-cells. High were observed TCM (central Intravenous administration a single 50 mg/kg dose recombinant antibody resulted significant initial decline lymphocytes sustained coating receptor both periphery tissues.
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