Temperament in child and adolescent offspring of patients with schizophrenia and bipolar disorder.

摘要: Shared vulnerability in offspring of individuals with schizophrenia (SzO) and bipolar disorder (BpO) might manifest early during development through common temperament traits. Temperament dimensions child adolescent BpO (N = 80), SzO 34) the community controls (CcO) 101) were assessed using Revised Dimensions Survey. The association between lifetime psychopathology (including threshold subthreshold DSM-IV-TR diagnoses) current socio-academic adjustment was logistic regression. Fully adjusted models showed that both scored significantly lower positive mood dimension adaptability factor than CcO, small-medium effect sizes (Cohen's d ~ 0.3-0.5). also activity CcO 0.3). Lower scores associated increased risk impaired [OR 2.30, 95% CI (1.18-4.46)] 2.87, (1.07-7.66)]. In BpO, likelihood internalizing 1.84, (1.28-2.64)] externalizing disorders 1.48, (1.01-2.18)]; SzO, higher flexibility 2.31, (1.22-4.38)] 3.28, (1.2-9)], respectively. Early difficulties emotion regulation represent a shared phenotype SzO. identification extreme traits could help to characterize subgroups at greater adjustment, which targeted interventions are warranted.