Postoperative serum methylation levels of TAC1 and SEPT9 are independent predictors of recurrence and survival of patients with colorectal cancer

摘要: BACKGROUND Serum carcinoembryonic antigen (CEA) is the only marker recommended for surveillance of colorectal cancer (CRC) recurrence; its sensitivity and specificity, however, are suboptimal. This study sought to evaluate values postoperative serum methylation levels 7 genes prognostication especially recurrence detection after curative resection. METHODS This prospective cohort included 150 patients with stage I-III CRC from whom 3 consecutive blood sampling was taken 1 week before, 6 months year operation. Methylation were evaluated via quantitative methylation-specific polymerase chain reaction. Serum CEA measured in parallel. Univariate multivariate survival analyses followed by construction receiver operating characteristic curves detection. RESULTS After a median follow-up 59 months, 43 (28.7%) developed recurrent lesions. High TAC1 at 6-month (6M-FU), SEPT9 1-year (1Y-FU) independent predictors tumor unfavorable cancer-specific (CSS) (P < .05 all tests). NELL1 significant alone CSS both 6M-FU 1Y-FU, but not disease-free survival. Dynamic changes increment also independently predictive More importantly, 1Y-FU exhibited earlier potential recurrences compared concurrent CEA. CONCLUSIONS Levels detected sera appear be novel promising prognostic markers may probably considered monitoring recurrence. Cancer 2014;120:3131–3141. © 2014 American Society.