Transetherification on polyols by intra- and intermolecular nucleophilic substitutions.

摘要: Transetherification on polyols involving intra- and intermolecular nucleophilic substitutions is reported. Di- or trialkoxide formation of propane-1,3-diol 2-(hydroxymethyl)propane-1,3-diol derivatives by NaH triggers the reaction via oxetanes formation, where order to add a polyol significantly influences yields products. It was demonstrated that protective group pentaerythritol skeleton apparently transferred hydrophilic hydrophobic chain molecules bearing leaving in one-step, conversion from tosyl benzyl successful using benzyl-appending triol afford desired product 67% yield.