Pancreatic pathology in type 1 diabetes in human.

摘要: In type 1 autoimmune diabetes there is a selective destruction of insulin-secreting beta cells. Around the time clinical presentation, insulitis, chronic inflammatory infiltrate islets affecting primarily insulin containing islets, present in majority cases. The consists T lymphocytes; CD8 cells outnumber CD4 cells, are fewer B lymphocytes and macrophages relatively scarce. cell death may involve Fas apoptotic pathway since they have been shown to express Fas, infiltrating Fas-L described. Hyperexpression class I MHC by all endocrine many insulin-containing well recognized phenomenon, characteristic disease. It has argued that this an earlier event than insulitis within given islet appears be due secretion interferon alpha islet. A recent study found evidence Coxsackie virus infection three out six pancreases patients with recent-onset diabetes. viruses known induce could initiate sequence events culminates their destruction.