Speculation on Prevention of Type 1 Diabetes

摘要: The increasing incidence, decreasing age of onset, and the lowered threshold for developing type 1 diabetes make its prevention even more imperative suggest changes over time in environmental etiologies contributing to disease. A testable hypothesis is that these epidemiological are arising from defective development or alteration intestinal microbiome-induced immunoregulation infancy early childhood. Viruses contribute microbiome microbial flora may be altered by enteric infections. In addition, viruses pathogenesis activation innate immunity and/or infection pancreatic beta cells islets ensuing inflammatory response, which lead cell stress with modification protein expression generate neoepitopes breaking immune tolerance native antigens. Both primary secondary childhood-onset should pursued on a childhood population-wide basis. Primary focus vaccines, including enteroviral vaccines if restricted number serotypes account significant proportion different geographical regions time. Vaccine-based approaches augment, accelerate, induce robust investigated.