Polymorphisms in Thioredoxin Reductase and Selenoprotein K Genes and Selenium Status Modulate Risk of Prostate Cancer

摘要: Increased dietary intake of Selenium (Se) has been suggested to lower prostate cancer mortality, but supplementation trials have produced conflicting results. Se is incorporated into 25 selenoproteins. The aim this work was assess whether risk affected by genetic variants in genes coding for selenoproteins, either alone or combination with status. 248 cases and 492 controls from an EPIC-Heidelberg nested case-control study were subjected two-stage genotyping initial screening phase which 384 tagging-SNPs covering 72 Se-related determined 94 using the Illumina Goldengate methodology. This analysis followed a second candidate SNPs identified first carried out full Sequenom. Risk high-grade advanced stage modified interactions between serum markers status genotypes rs9880056 SELK, rs9605030 rs9605031 TXNRD2, rs7310505 TXNRD1. No significant effects on observed when grade not taken account. In conclusion, advanced-stage significantly altered genotype selenoprotein findings contribute explaining biological selenium factors development highlight potential roles thioredoxin reductases K tumour progression.