Effects of microRNA-21 on the biological functions of T-cell acute lymphoblastic lymphoma/leukemia

摘要: Previous studies have demonstrated that microRNA-21 (miR-21) is an oncogene and significantly upregulated in tumor tissue. However, its association with T-cell acute lymphoblastic lymphoma/leukemia (T-ALL) remains poorly understood. The aim of the present study was to investigate effects miR-21 on T-ALL cells by constructing Jurkat infected recombinant adenovirus adv-miR-21 or adv-anti-miR-21. In addition, target gene identified reverse transcription-quantitative polymerase chain reaction western blotting. results expression markedly upregulated. Furthermore, upregulating promoted cell proliferation invasion decreased apoptosis rate. By contrast, knockdown suppressed increased indicated signal transducer activator transcription (STAT) 3 targeted miR-21, inhibited STAT3 at protein level rather than messenger RNA level. conclusion, targeting inhibition may be a novel therapeutic strategy for patients T-ALL.