Development and characterisation of novel cross-linked bio-elastomeric materials.
作者： Elizabeth M. Srokowski , Kimberly A. Woodhouse
DOI: 10.1163/156856208784522038
关键词: Lysine diisocyanate 、 Polymer chemistry 、 Porous medium 、 Material properties 、 Materials science 、 Swelling 、 Chemical engineering 、 Thermal stability 、 Elastomer 、 Porosity 、 Calorimetry
摘要: Recombinantly-engineered elastin-like polypeptides (ELPs) possess many of the favourable attributes native elastin protein, making them an attractive option for designing biomaterials tissue-engineering applications. The focus this study was to synthesize and characterise bulk material properties two ELP sequences, ELP2 ELP4, cross-linked with lysine diisocyanate (LDI). distinct ELPs consist repeating hydrophobic hydrophilic cross-linking domains in a block co-polymer structure, however, differ by number respective domains. Depending on conditions sets reactions, different ELP-based materials were synthesized: gel-like relatively non-porous porous foam-like material, from both sequences. physical characterised scanning electron microscopy, compression testing, differential calorimetry analysis swelling analysis. found vary depending t...
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