Cutting Edge: Cytolytic Effector Function in Human Circulating CD8+T Cells Closely Correlates with CD56 Surface Expression
作者： Mikaël J Pittet , Daniel E Speiser , Danila Valmori , Jean-Charles Cerottini , Pedro Romero
DOI: 10.4049/JIMMUNOL.164.3.1148
关键词: T cell 、 CD8 、 Neural cell adhesion molecule 、 Cytotoxic T cell 、 Interleukin 21 、 Granzyme 、 Biology 、 Effector 、 Perforin 、 Cell biology 、 Immunology
摘要: Recent data suggest that human effector CD8+ T cells express a distinct CD27-CD45RAhigh (CD57+CD28-CD11ahigh) phenotype. Here, we propose CTL function correlates better with CD56 (neuronal cell adhesion molecule (NCAM)) surface expression. was absent on cord blood cells, but expressed by 4-30% of freshly isolated circulating from 15 adults. Dramatic oligoclonal expansions in 3/3 individuals were confined to the CD56+ subset cells. The generally contained high amounts intracellular perforin and granzyme B. Finally, direct cytolytic capacity closely restricted CD56+(CD45RAhigh) than 5/5 analyzed. Thus, phenotype corresponding pool may be simplified more precisely defined use just two markers: CD8 CD56.
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