The interrelationship between sex, susceptibility factors, and outcome in ankylosing spondylitis and its associated disorders including inflammatory bowel disease, psoriasis, and iritis

摘要: OBJECTIVE: To examine the evidence that families, where mother has disease, carry more heritable factors and investigate effect of maternal/paternal inheritance on phenotypic expression disease in terms (a) severity outcome (b) additional co-disorders. The children women with ankylosing spondylitis (AS) develop often than men. This suggests either susceptibility men or uterine environment/breast feeding may play a role AS. METHODS: number second degree relatives (i.e., grandparent, aunt/uncle) was calculated for those index patients as opposed to father. Outcome measures were compared prevalence secondary disorders psoriasis, iritis, inflammatory bowel disease) examined an AS RESULTS: affected offspring maternal cases had [20% vs 9%, respectively, p = 0.012, odds ratio (OR): 2.3, 95% confidence interval (CI): 1.2, 4.5] did comparable activity, function, radiology father disease. Inflammatory prevalent among mothers fathers (15% 5%, 0.009, OR: 2.9, CI: 1.3, 6.3). Psoriasis less sons (9% 22%, 0.03, 0.4, 0.2, 0.9). CONCLUSION: inherited load is strongly linked sex parent Women higher heritability (which associated do There male impact psoriasis (when present). However, there no (as measured by radiology), influenced transmission paternal factors.