Improved fractional precipitation method for purification of paclitaxel
作者： Chung-Gi Lee , Jin-Hyun Kim
DOI: 10.1016/J.PROCBIO.2014.04.011
关键词: Yield (chemistry) 、 Distilled water 、 Methanol 、 Analytical chemistry 、 Mixing (process engineering) 、 Fractional Precipitation 、 Materials science 、 Applied Microbiology and Biotechnology 、 Biochemistry 、 Bioengineering
摘要: Abstract This study investigated changing the methanol/water ratio during fractional precipitation of paclitaxel, and adding all distilled water at room temperature, followed mixing for an additional 10 min. When was 50:50, 40:60, 30:70 (v/v), paclitaxel yield 42.0%, 84.3%, 92.0%, respectively. using a 50:50 similar high purity to case storing low temperature achieved when by 10 min further precipitation. Thus, after is confirmed as important Furthermore, present results show that high-purity possible with water, which significantly more economical than existing method long time
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sci-hub.se 参考文章(20)
Jin-Hyun Kim, In-Seon Kang, Hyung-Kyoon Choi, Seung-Suh Hong, Hyun-Soo Lee, Fractional precipitation for paclitaxel pre-purification from plant cell cultures of Taxus chinensis Biotechnology Letters. ,vol. 22, pp. 1753- 1756 ,(2000) , 10.1023/A:1005642001815
Koppaka V. Rao, Jampani B. Hanuman, Claudio Alvarez, Mark Stoy, John Juchum, Richard M. Davies, Ronald Baxley, A New Large-Scale Process for Taxol and Related Taxanes from Taxus brevifolia Pharmaceutical Research. ,vol. 12, pp. 1003- 1010 ,(1995) , 10.1023/A:1016206314225
Jeong-Hwan Yun, Seung-Suh Hong, Sang-Ic Kim, Hyung-Kyoon Choi, Bong-Kyu Song, Jun-Seog Song, Roy William Stahlhut, Jin-Hyun Kim, Tom Lee Adams, Hyun-Soo Lee, Method for mass production of taxol by semi-continuous culture with Taxus chinensis cell culture ,(1996)
김진현, Paclitaxel : 산업화 단계에서의 회수 및 정제 KSBB Journal. ,vol. 21, pp. 1- 10 ,(2006)
Erkan Baloglu, David G. I. Kingston, A new semisynthesis of paclitaxel from baccatin III. Journal of Natural Products. ,vol. 62, pp. 1068- 1071 ,(1999) , 10.1021/NP990040K
G. B. RYAN, J. P. COGHLAN, B. A. SCOGGINS, The granulated peripolar epithelial cell: a potential secretory component of the renal juxtaglomerular complex Nature. ,vol. 277, pp. 655- 656 ,(1979) , 10.1038/277655A0
Insoo Kang, Jin-Hyun Kim, Effect of Reactor Type on the Purification Efficiency of Paclitaxel in the Increased Surface Area Fractional Precipitation Process Separation and Purification Technology. ,vol. 99, pp. 14- 19 ,(2012) , 10.1016/J.SEPPUR.2012.08.025
Keum-Young Jeon, Jin-Hyun Kim, Improvement of fractional precipitation process for pre-purification of paclitaxel Process Biochemistry. ,vol. 44, pp. 736- 741 ,(2009) , 10.1016/J.PROCBIO.2009.03.007
Min-Gyeong Han, Keum-Young Jeon, Sungyong Mun, Jin-Hyun Kim, Development of a micelle-fractional precipitation hybrid process for the pre-purification of paclitaxel from plant cell cultures Process Biochemistry. ,vol. 45, pp. 1368- 1374 ,(2010) , 10.1016/J.PROCBIO.2010.05.010
Hyung-Kyoon Choi, Joo-Sun Son, Gwang-Hwee Na, Seung-Suh Hong, Yeon-Seung Park, Jai-Young Song, Mass Production of Paclitaxel by Plant Cell Culture Journal of Plant Biotechnology. ,vol. 29, pp. 59- 62 ,(2002) , 10.5010/JPB.2002.29.1.059