Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells.
作者： Claudiane Guay , Véronique Menoud , Sophie Rome , Romano Regazzi
DOI: 10.1186/S12964-015-0097-7
关键词: Microvesicles 、 Signal transduction 、 Cell culture 、 Receptor 、 Metabolic disorder 、 Cell biology 、 Cell 、 Apoptosis 、 microRNA 、 Biology
摘要: Background Diabetes mellitus is a common metabolic disorder characterized by dysfunction of insulin-secreting pancreatic beta-cells. MicroRNAs are important regulators beta-cell activities. These non-coding RNAs have recently been discovered to exert their effects not only inside the cell producing them but, upon exosome-mediated transfer, also in other recipient cells. This novel communication mode remains unexplored In present study, microRNA content exosomes released beta-cells physiological and physiopathological conditions was analyzed biological impact transfer cells investigated.
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