Minority HIV-1 Drug Resistance Mutations Are Present in Antiretroviral Treatment–Naïve Populations and Associate with Reduced Treatment Efficacy

作者: Jeffrey A Johnson , Jin-Fen Li , Xierong Wei , Jonathan Lipscomb , David Irlbeck

DOI: 10.1371/JOURNAL.PMED.0050158

关键词: VirologyImmunologyCase-control studyDrug resistanceGenotypeTreatment efficacyAntiretroviral therapyPharmacotherapyGenotypingAntibiotic resistanceMedicine

摘要: … Funding: This work was supported by the Centers for Disease Control and Prevention. There … The frequent occurrence of drug resistance likely reflects a high prevalence of ART in these …

参考文章(26)
Birgitte B. Simen, Jan Fredrik Simons, Katherine Huppler Hullsiek, Richard M. Novak, Rodger D. MacArthur, John D. Baxter, Chunli Huang, Christine Lubeski, Gregory S. Turenchalk, Michael S. Braverman, Brian Desany, Jonathan M. Rothberg, Michael Egholm, Michael J. Kozal, , Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes. The Journal of Infectious Diseases. ,vol. 199, pp. 693- 701 ,(2009) , 10.1086/596736
Gonzague Jourdain, Nicole Ngo-Giang-Huong, Sophie Le Coeur, Chureeratana Bowonwatanuwong, Pacharee Kantipong, Pranee Leechanachai, Surabhon Ariyadej, Prattana Leenasirimakul, Scott Hammer, Marc Lallemant, Intrapartum exposure to nevirapine and subsequent maternal responses to nevirapine-based antiretroviral therapy. The New England Journal of Medicine. ,vol. 351, pp. 229- 240 ,(2004) , 10.1056/NEJMOA041305
Jeffrey A. Johnson, Jin-Fen Li, Xierong Wei, Jonathan Lipscomb, Diane Bennett, Ashley Brant, Mian-er Cong, Thomas Spira, Robert W. Shafer, Walid Heneine, Simple PCR Assays Improve the Sensitivity of HIV-1 Subtype B Drug Resistance Testing and Allow Linking of Resistance Mutations PLoS ONE. ,vol. 2, pp. e638- ,(2007) , 10.1371/JOURNAL.PONE.0000638
Robert M Grant, Frederick M Hecht, Maria Warmerdam, Lea Liu, Teri Liegler, Christos J Petropoulos, Nicholas S Hellmann, Margaret Chesney, Michael P Busch, James O Kahn, Time Trends in Primary HIV-1 Drug Resistance Among Recently Infected Persons JAMA. ,vol. 288, pp. 181- 188 ,(2002) , 10.1001/JAMA.288.2.181
Bluma Brenner, Jean-Pierre Routy, Yudong Quan, Daniela Moisi, Maureen Oliveira, Dan Turner, Mark A Wainberg, Persistence of multidrug-resistant HIV-1 in primary infection leading to superinfection. AIDS. ,vol. 18, pp. 1653- 1660 ,(2004) , 10.1097/01.AIDS.0000131377.28694.04
Gayatri C. Jayaraman, Chris P. Archibald, John Kim, Michael L. Rekart, Ameeta E. Singh, Sonia Harmen, Michelyn Wood, Paul Sandstrom, A population-based approach to determine the prevalence of transmitted drug-resistant HIV among recent versus established HIV infections: results from the Canadian HIV strain and drug resistance surveillance program. Journal of Acquired Immune Deficiency Syndromes. ,vol. 42, pp. 86- 90 ,(2006) , 10.1097/01.QAI.0000196666.16616.FE
Edwin DeJesus, Gisela Herrera, Eugenio Teofilo, Jan Gerstoft, Carlos Beltran Buendia, J. David Brand, Cynthia H. Brothers, Jaime Hernandez, Steve A. Castillo, Tab Bonny, E. Randall Lanier, Trevor R. Scott, , Abacavir versus zidovudine combined with lamivudine and efavirenz, for the treatment of antiretroviral-naive HIV-infected adults. Clinical Infectious Diseases. ,vol. 39, pp. 1038- 1046 ,(2004) , 10.1086/424009
R. T. Gandhi, A. Wurcel, E. S. Rosenberg, M. N. Johnston, N. Hellmann, M. Bates, M. S. Hirsch, B. D. Walker, Progressive reversion of human immunodeficiency virus type 1 resistance mutations in vivo after transmission of a multiply drug-resistant virus. Clinical Infectious Diseases. ,vol. 37, pp. 1693- 1698 ,(2003) , 10.1086/379773
HULDRYCH F. GÜNTHARD, JOSEPH K. WONG, CAROLINE C. IGNACIO, DIANE V. HAVLIR, DOUGLAS D. RICHMAN, Comparative Performance of High-Density Oligonucleotide Sequencing and Dideoxynucleotide Sequencing of HIV Type 1 pol from Clinical Samples AIDS Research and Human Retroviruses. ,vol. 14, pp. 869- 876 ,(1998) , 10.1089/AID.1998.14.869
GJ Moyle, E DeJesus, P Cahn, S Castillo, Henry Zhao, David Gordon, Charles Craig, Trevor Scott, for the Ziagen Once-Daily in Antiretroviral Combination Therapy (CNA30021) Study Team, None, Abacavir once or twice daily combined with once-daily lamivudine and efavirenz for the treatment of antiretroviral-naive HIV-infected adults: results of the Ziagen Once Daily in Antiretroviral Combination Study. Journal of Acquired Immune Deficiency Syndromes. ,vol. 38, pp. 417- 425 ,(2005) , 10.1097/01.QAI.0000147521.34369.C9