Squamous cell carcinoma of the vagina: natural history, treatment modalities and prognostic factors.

摘要: Squamous cell carcinoma of the vagina accounts for less than 2% all gynecologic malignancies. Surgery has a role in selected cases only. The standard treatment is radiotherapy, external beam radiation and/or brachytherapy, depending on extent, thickness, location and morphology lesion. chemotherapy still under evaluation. Radiotherapy obtained 5-year overall survival rates ranged from 35% to 78%, with severe late complication 9.4-23.1%. Tumor stage strongest prognostic factor. size >4cm, tumor outside upper third vagina, old age at presentation are additional predictors poor most papers, whereas value histological grade, prior hysterectomy, hemoglobin levels controversial. High-risk HPV DNA low MIB-1 index associated better clinical outcome. Because rarity this tumor, future multicenter studies would be strongly warranted.