Initial CT manifestations of invasive pulmonary aspergillosis in 45 non-HIV immunocompromised patients: association with patient outcome?

摘要: Abstract Purpose: To assess early high-resolution computer tomographic (CT) signs of invasive pulmonary aspergillosis (IPA) in non-HIV immunosuppressed patients and their potential association with patient's outcome, including frequency severity hemorrhage, taking also consideration the impact other known risk factors contributory to IPA. Material methods: A retrospective review serial CT scans was performed 45 immunocompromised a total 46 episodes aspergillosis. All underwent beginning day they showed clinical or laboratory infection. Serial follow-up included more than two, up 12 examinations. Patient's outcome judged by radiological classified as survival, death IPA, unrelated The influence age, underlying disease, hematopoietic stem cell transplantation, neutropenia, graft versus host antifungal therapy onset statistically considered. Results: Three main findings were identified: small nodules ( Conclusion: Initial consist mainly patchy consolidations, showing 82% cases an halo sign. Serious hemorrhage infrequent complication our series, attributable mortality 4.3%. IPA-related lethality 26%, cohort. None HRCT seemed predict outcome.