Predicting recurrence after oral precancer treatment: Use of cell cycle analysis

摘要: Prediction of the behaviour oral precancerous lesions (OPLs) is unreliable in clinical practice. The aim this study was to analyse efficacy cell cyclin markers A and B1, proliferative marker Ki67, predicting outcome for patients with OPLs. cohort previously-treated single OPLs were retrieved from MaxilloFacial Dysplasia database reviewed. All had dysplastic excised by laser followed up 5 years post-treatment. Outcome determined as no recurrence or further disease. Excision specimens re-examined immunohistochemically labelling indices (LIs) A, B1 Ki67 determined. Forty patients, aged between 31 91 years, recruited. There differences age sex. predominantly leukoplakias on floor mouth ventro-lateral tongue (65%), most which exhibited moderate severe dysplasia. Cyclin LIs ranged 3.9% 31.3%, 0 28.3% 3.5% 54.5%. Using median 'cut off points' (12% cyclins; 22% Ki67) Kaplan-Meier survival analysis showed a significant risk progression disease OPL exceeding values (Cyclin p=0.02, p=0.01, p=0.025). By combining both B LI, significance difference increased (p<0.01). Cell cycle effective identifying at following treatment Multi-centre, longitudinal trials are needed assess precise role their management.