Frequent Microsatellite Instability in Primary Small Cell Lung Cancer

摘要: Alterations in microsatellite sequences characterize hereditary nonpolyposis colorectal cancer. This instability is due some kindreds to a germline mutation of the mismatch repair gene hMSH2 on chromosome 2p. Although alterations have been reported other cancer-associated tumors including endometrial and gastric cancers, such changes were not detected most major neoplasms. We found that 15 33 (45%) primary small cell lung cancer syndrome, displayed loci which consisted deletions or expansions (CA)n dinucleotide repeats. In 8 these neoplasms, was more than 10% all tested alleles. However, cancers revealed contained widespread allelic loss had uniformly poor prognosis. These results expand considerably known spectrum with instability.