Comparison between VP 16 and VM 26 in Lewis lung carcinoma of the mouse
作者： T. Colombo , M. Broggini , M. Vaghi , G. Amato , E. Erba
DOI: 10.1016/0277-5379(86)90027-1
关键词: Lewis lung carcinoma 、 Ratón 、 Flow cytometry 、 Immunology 、 Volume of distribution 、 Molecular biology 、 Cytotoxic T cell 、 Teniposide 、 Pharmacokinetics 、 Distribution (pharmacology) 、 Medicine
摘要: Abstract The antitumoral activity and pharmacokinetics of VP 16 VM 26 were comparatively investigated in Lewis lung carcinoma (3LL)-bearing mice. When the two drugs given at equitoxic doses, single or repeated treatment, superior was clear. Compared to 16, had a different pattern distribution, with large volume longer elimination half-life time lower clearance. tissue plasma AUC ratios indicated that concentrated more tumor heart while gave highest concentrations liver intestine. Flow cytometry studies showed potent than causing cell cycle perturbation 3LL cells growing primary culture. displayed cytotoxic concentration medium one-tenth 16. uptake by 15 times
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