Nephrotic range proteinuria and CD4 count as noninvasive indicators of HIV-associated nephropathy

摘要: Abstract Purpose Human immunodeficiency virus (HIV)-associated nephropathy is a common and serious cause of progressive renal insufficiency in patients with HIV, frequently presenting nephrotic range proteinuria. The purpose this study to document the histopathologic diagnoses seen HIV-positive without proteinuria evaluate predictive value both CD4 count diagnosing HIV-associated nephropathy. Methods We performed cross-sectional, single-center all 107 who had biopsy urine protein measurement between 1995 2002. Nephrotic was defined as protein-to-creatinine ratio > 3 or 24-hour g. Clinical laboratory characteristics those were compared. Sensitivity, specificity, positive negative values diagnosis determined. Results Fifty-five biopsied proteinuria, among whom 29 (53%) diagnosed Among remaining patients, 12 non-HIV-associated focal segmental glomeruloscerlosis, membranoproliferative glomerulonephritis, 2 AA Amyloid, diabetic nephropathy, 7 other diagnoses. 73%, 61%, 53%, 79%, respectively. significantly higher creatinine (8.2 mg/dL vs 2.5 mg/dL, P 349 count/mm , = .03), below 200, 10 30 (33%) than Injection drug use, presence hepatitis C, hypertension not associated Conclusion Our results suggest that HIV warrant kidney because even low count, does establish