HIV-Associated Nephropathy in the Era of Antiretroviral Therapy

摘要: With improved survival in the era of antiretroviral therapy, kidney disease has emerged as an important complication Human Immunodeficiency Virus (HIV) infection and therapy. The classic HIV infection, HIV-associated nephropathy, occurs almost exclusively patients African descent. nephropathy is characterized by collapsing focal segmental glomerulosclerosis with associated tubular dilatation interstitial inflammation, although histology may be more subtle receiving Renal epithelial cells are infected HIV-1, which results cell proliferation induction local inflammatory pathways. Even appropriate a reservoir for HIV-1. Although widespread introduction therapy had beneficial impact on epidemiology burden likely to increase result toxicity, reduction competing mortality risks, increasing prevalence HIV-1 at risk disease.