Effect of carminomycin on the viability of fibroblasts from patients with regular trisomy 21.
作者： Błazej Rózga , Alexander V. Peskin , Grzegorz Bartosz
DOI: 10.3109/10715769009087977
关键词: Chromosome 21 、 Fibroblast 、 Dismutase 、 Biology 、 Antibiotics 、 Anthracycline 、 Trisomy 、 Molecular biology 、 Dose–response relationship 、 Cytotoxic T cell
摘要: The sensitivity of three human fibroblast lines, trisomic with respect to chromosome 21, an anthracycline antibiotic carminomycin was compared that a normal line using 51Cr release assay. It found for intermediate concentration (10 microM) the fibroblasts, increased content Cu,Zn-superoxide dismutase lower. These results suggest role superoxide-mediated membrane damage in cytotoxic action antibiotics.
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