Transcranial direct current stimulation over the right DLPFC selectively modulates subprocesses in working memory.

摘要: Background Working memory, as a complex system, consists of two independent components: manipulation and maintenance process, which are defined executive control storage process. Previous studies mainly focused on the overall effect transcranial direct current stimulation (tDCS) working memory. However, little has been known about segregative effects tDCS sub-processes within Method Transcranial stimulation, one non-invasive brain techniques, is being widely used to modulate cortical activation local areas. This study modified spatial n-back experiment with anodal cathodal exertion right dorsolateral prefrontal cortex (DLPFC), aiming investigate memory: (updating) maintenance. Meanwhile, considering separability effects, we further reconfirmed causal relationship between DLPFC memory different conditions. Results The present showed that selectively improved performance 2-back task in difficult condition, whereas significantly reduced subjects an speeding-up tendency response time. More precisely, results discriminability index criterion only enhanced condition. Neither conditions affected (updating). Conclusion These findings provide evidence affects capacity. Besides, also serves interference suppressor reduce irrelevant interference, thereby indirectly improving Moreover, not unique regions for