The ras Gene Family
作者： Christopher J. Marshall
DOI: 10.1007/978-3-642-73325-3_26
关键词: GTP' 、 P21 RAS Protein 、 GTPase 、 Genetics 、 Oncogene 、 Gene 、 Pseudogene 、 HRAS 、 Biology 、 Neuroblastoma RAS viral oncogene homolog
摘要: The ras gene family in mammalian cells consists of five closely related members: the Harvey and Kirsten genes (c-Ha-ras1 c-Ki-ras2), an inactive pseudogene each (c-Ha-ras2 c-Ki-ras1; see Hall 1984) N-ras gene. There are also several distinctly designated rho (ras-homologous; Madaule Axel 1985). In addition to their sequence homology, by fact that they encode protein products approximately 21 kDa (p21 ) which share properties GTP/GDP binding, weak GTPase activity presence C-terminal cysteine residues (potential palmitation sites for membrane localization). past years, a growing body evidence has implicated as playing role wide variety human cancers. comes largely from studies indicating 10–20% most types malignancies contain “activated” oncogene is capable inducing transformed foci following transfer into recipient such mouse NIH-3T3. This chapter discusses three aspects genes: structure expression, mechanism activation tumours, biochemistry p21 protein. Additional covered chapters Fasano Masters Bourne this Volume.
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