Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome
作者： Yoshio Yaoita , Tasuku Honjo
DOI: 10.1038/286850A0
关键词: Molecular biology 、 Chromosome 、 Antibody 、 Genetics 、 Southern blot 、 Biology 、 Gene 、 Allotype 、 Allele 、 Immunoglobulin Heavy Chain Genes
摘要: We have studied the organization of immunoglobulin heavy-chain genes in a γ2b-chain (BALB/c allotype)-producing myeloma BKC F1 #15 induced mouse between C57BL and BALB/c. Southern blot hybridization studies using cloned μ, γ1 as probes demonstrate that μ- γ1-chain expressed chromosome are deleted while these unexpressed retained. The gene allele is rearranged seems unchanged, do γ2a-chain genes. These results support allelic deletion mechanism class switch order H chain
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