Expression of serum miR-16, let-7f, and miR-21 in patients with hepatocellular carcinoma and their clinical significances.

摘要: BACKGROUND Recent studies showed that serum microRNAs were aberrantly expressed in cancers, including hepatocellular carcinoma (HCC). Serum microRNA (miRNA) profiles HCC have been filtered our previous studies. In this research, some miRNAs further validated and their clinical significances analyzed. METHODS Sera from 90 patients, the subjects, 60 non-HCC normal, controls, used. The expression of was measured using real-time reverse transcription-polymerase chain reaction. AFP, as well other materials, summarized databases hospital. RESULTS miR-16, let-7f, miR-21 are down-regulated while miR-98 miR-221 not regulated significantly. Moreover, these specific significance. miR-16 is patients with a tumor more than 5 cm diameter (p = 0.0013) correlated quantitative features such platelets 0.0255), PT 0.0007) bilirubin 0.0025). let-7f up-regulated 0.0367) early recurrence 0.0047). female 0.0297). CONCLUSIONS related biological behavior HCC, which means they could be considered potential indicators to estimate size or HCC.