Recent Advancements in DNA Damage–Transcription Crosstalk and High-Resolution Mapping of DNA Breaks

摘要: Until recently, DNA damage arising from physiological metabolism was considered a detrimental by-product for cells. However, an increasing amount of evidence has shown that could have positive role in transcription activation. In particular, been detected transcriptional elements following different stimuli. These breaks are thought to be instrumental the correct expression genomic loci through mechanisms. this regard, although plethora methods available precisely map transcribed regions and start sites, commonly used techniques mapping lack sufficient resolution sensitivity draw robust correlation between generation transcription. Recently, however, several developed at single-nucleotide resolution, thus providing new set tools correlate Here, we review how can positively regulate initiation, current high these benefit future studies