Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them

摘要: Disclosed are novel carboxyalkyl dipeptides which useful as inhibitors of angiotensinconverting enzyme and antihypertensive agents, having the formula pharmaceutically acceptable salts thereof, wherein R R6 for example hydroxy, lower alkoxy or arylloweralkoxy; R' is hydrogen, alkyl, aryloxy; R2 same different hydrogen alkyl; R3 alkyl phenyl R4 R5 selected from Z, taken together form a group represented by Q, U, V, Y, D E X' X2 independent each other 0, S CH2, R8 R9 alkenyl, alkynyl, cycloalkyl 3 to 8 carbon atoms, hydroxy -(CH2)nAr, n 1, 2 bridge W, W single bond methylene substituted when at least one methylene, an alkylene atoms; with proviso that Z; L O S. The compounds can be prepared according known methods such condensation aminoacid XXI XVII X1, defined above; G oxygen, sulfur CH2;