Modern management of cryptorchidism: which evidences?

作者: Paolo Caione , Roberto Tambucci

DOI: 10.5301/URO.5000086

关键词: Testicular cancerInfertilityPopulationOrchiopexyInguinal canalMedicineLaparoscopyGubernaculumScrotumUrology

摘要: The term cryptorchidism is related to the failure of migration testis scrotum. In most cases, are retained along physiological route through inguinal canal. 1% cases gubernaculum abnormally fixed (testicular ectopy).In 20% one not clinically palpable. US has a sensitivity 45% and specificity 78% in detecting intra-abdominal testis. Consequently, laparoscopy should be considered gold-standard these cases.Hormonal therapy been order aid testicular descent, without or before surgery. Recent data suggest that strategies seem have success rate 10% higher than placebo, while surgery alone effective 33-100% cases.Several histological studies showed microscopic damages due since age 6-9 months. Some Authors up 40% completely lose their own germinal cells pool at two years. Consequently guide-lines proposed 6-18 months.Cancer relative risk associated calculated 1.5-7.5% general population lower what traditionally estimated (15-33%). Moreover, this increases 2.9-32.0 times when performed after 10-11

参考文章(24)
Kwan Hyun Park, Joo Hwan Lee, Jae Joon Han, Sang Don Lee, Sang Yong Song, Histological evidences suggest recommending orchiopexy within the first year of life for children with unilateral inguinal cryptorchid testis. International Journal of Urology. ,vol. 14, pp. 616- 621 ,(2007) , 10.1111/J.1442-2042.2007.01788.X
W. W. M. Hack, J. Goede, L. M. van der Voort-Doedens, R. W. Meijer, Acquired undescended testis: putting the pieces together. International Journal of Andrology. ,vol. 35, pp. 41- 45 ,(2012) , 10.1111/J.1365-2605.2011.01155.X
Emily Chan, , Carolyn Wayne, Ahmed Nasr, Ideal timing of orchiopexy: a systematic review Pediatric Surgery International. ,vol. 30, pp. 87- 97 ,(2014) , 10.1007/S00383-013-3429-Y
JM Stone, DG Cruickshank, TF Sandeman, JP Matthews, Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, Australia. British Journal of Cancer. ,vol. 64, pp. 132- 138 ,(1991) , 10.1038/BJC.1991.256
Bojan Trsinar, Ursula Res Muravec, Fertility potential after unilateral and bilateral orchidopexy for cryptorchidism World Journal of Urology. ,vol. 27, pp. 513- 519 ,(2009) , 10.1007/S00345-009-0406-0
Lydia Ferguson, Alexander I. Agoulnik, Testicular cancer and cryptorchidism. Frontiers in Endocrinology. ,vol. 4, pp. 32- 32 ,(2013) , 10.3389/FENDO.2013.00032
Gregory E. Tasian, Adam B. Hittelman, Grace E. Kim, Michael J. DiSandro, Laurence S. Baskin, Age at Orchiopexy and Testis Palpability Predict Germ and Leydig Cell Loss: Clinical Predictors of Adverse Histological Features of Cryptorchidism Journal of Urology. ,vol. 182, pp. 704- 709 ,(2009) , 10.1016/J.JURO.2009.04.032
Thomas J. Walsh, Marc A. Dall’Era, Mary S. Croughan, Peter R. Carroll, Paul J. Turek, Prepubertal Orchiopexy for Cryptorchidism May be Associated With Lower Risk of Testicular Cancer Journal of Urology. ,vol. 178, pp. 1440- 1446 ,(2007) , 10.1016/J.JURO.2007.05.166
Thomas F Kolon, CD Anthony Herndon, Linda A Baker, Laurence S Baskin, Cheryl G Baxter, Earl Y Cheng, Mireya Diaz, Peter A Lee, Carl J Seashore, Gregory E Tasian, Julia S Barthold, None, Evaluation and Treatment of Cryptorchidism: AUA Guideline The Journal of Urology. ,vol. 192, pp. 337- 345 ,(2014) , 10.1016/J.JURO.2014.05.005