Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease.

摘要: Apolipoprotein E ɛ4 allele is a common susceptibility gene for late-onset Alzheimer's disease. Brain vascular and metabolic deficits can occur in cognitively normal apolipoprotein carriers decades before the onset of The goal this study was to determine whether early intervention using rapamycin could restore neurovascular neurometabolic functions, thus impede pathological progression disease-like symptoms pre-symptomatic transgenic mice. Using in vivo, multimodal neuroimaging, we found that mice treated with had restored cerebral blood flow, blood–brain barrier integrity glucose metabolism, compared age- gender-matched wild-type controls. preserved vasculature metabolism were associated amelioration incipient learning deficits. We also levels proinflammatory cyclophilin A vasculature, which may contribute preservation cer...