Natural mutation rates in the house mouse estimates for five specific loci and dominant mutations
作者： Gunther Schlager , Margaret M. Dickie
DOI: 10.1016/0027-5107(71)90034-0
关键词: Genetics 、 House mouse 、 BALB/c 、 Mutation rate 、 Gamete 、 Locus (genetics) 、 Mutant 、 Allele 、 Spontaneous mutation 、 Biology 、 Health, Toxicology and Mutagenesis 、 Molecular biology
摘要: Abstract More than 7 million mice were examined for grossly visible spontaneous mutations. A total of 249 mutations recovered, which 206 could be characterized as their mode inheritance (dominant or recessive). The rates at 5 specific coat-color loci (a, b, c, d, and ln) 11 · 10−6 per locus gamete from wild-type, 2.5 recessive alleles. Large differences found between the individual loci; a, a+, c+ alleles had highest rates. Estimates “forward” “reverse” each these five also showed large differences. comparison those other dominant recovered that used in this study a mutation rate 6 times higher. No effect age parent was discernible where sufficient numbers mutants to make meaningful comparison.
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