Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation

摘要: Atherosclerotic lesion development was assessed in the thoracic aorta and chronically denuded iliac-femoral artery of hypercholesterolemic New Zealand White rabbits using inhibitors 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase which have previously been shown to possess varying degrees hepatoselectivity rats. Atorvastatin, known as CI-981 (2.5 mg/kg), PD135022 (1.0 simvastatin lovastatin PD134965 pravastatin mg/kg) BMY22089 were added a 0.5% cholesterol, 3% peanut, coconut oil diet fed for 8 weeks. Although reductions plasma total cholesterol 27% 60%, VLDL-cholesterol 31% 71% exposure 37% 43% obtained, no correlation between these parameters vascular lipid content, size or monocyte-macrophage content noted. Iliac-femoral unchanged; however, atorvastatin significantly reduced by 45%-62%. Atorvastatin 67% 72%. Simvastatin, decreased content; unchanged. Pravastatin had effect on content. No compound extent aortic lesions. We concluded that changes lipids lipoproteins noted with various HMG-CoA did not account beneficial atherosclerotic development. The antiatherosclerotic potential compound-specific clearly class effect.