Influence of mevinolin on experimental atherosclerosis in rabbits
作者： David Kritchevsky , Shirley A. Tepper , David M. Klurfeld
DOI: 10.1016/S0031-6989(81)80063-X
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摘要: Summary Two groups of eight rabbits each were fed an atherogenic diet (2% cholesterol in 6% corn oil) for weeks. One group was given a daily oral dose 2.5 mg/kg mevinolin, potent inhibitor HMG-CoA reductase. The test compound by gavage dissolved 0.5 ml dimethyl-sulfoxide. control the vehicle alone. Rabbits treated with mevinolin exhibited significantly lower serum levels and less severe atherosclerosis.
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