Allometry and Scaling of the Intraocular Pressure and Aqueous Humour Flow Rate in Vertebrate Eyes

摘要: In vertebrates, intraocular pressure (IOP) is required to maintain the eye into a shape allowing it function as an optical instrument. It sustained by balance between production of aqueous humour ciliary body and resistance its outflow from eye. Dysregulation IOP often pathological vision. High may lead glaucoma, which in man second most prevalent cause blindness. Here, we examine importance rate formation development vertebrate eyes performing allometric scaling analyses forces acting on during head movement energy demands cornea, testing predictions models against list measurements vertebrates collated through systematic review. We show that has weak dependence mass, order focal length eye, needs be magnitude greater than drop across resulting gravity or movement. This constitutes evolutionary constraint common all vertebrates. animals with cornea-based optics, this also represents condition visual acuity. Estimated IOPs were found increase evolution terrestrial animals. The was adjusted metabolic requirements Vac(0.67), where Vac volume anterior chamber. present work highlights interdependence flow crucial ocular must considered understand dioptric apparatus. should taken consideration prevention treatment glaucoma.