Pharmacokinetics of parenteral and oral sustained-release morphine sulphate in dogs.

摘要: The pharmacokinetics of single-dose morphine sulphate (MS) administered intravenously (i.v.) and intramuscularly (i.m.) oral sustained-release (OSRMS) were studied in dogs. Beagles (n = 6) randomly assigned to six treatment groups using a Latin square design. Treatments included MS 0.5 0.8 mg/kg i.v. i.m. OSRMS 15 30 mg orally (p.o). Serum samples drawn at intervals up 420 min following parenteral 720 OSRMS. was analysed for concentration radioimmunoassay. Pharmacokinetic analysis the results revealed that eliminated by first-order process best described two-compartment model. For data there no statistically significant differences (P < 0.05) between steady-state volume distribution, half-life elimination plasma clearance. As expected, area under vs. time curve (AUC) significantly greater dosage routes, maximum serum longer administration. any parameter (AUC, Cmax, tmax, t1/2, F) prolonged absorption drug occurred over approximately 6 h. Bioavailability (F) both dosages 20%. route is an effective method rapid complete delivery may be useful provision long-term analgesic therapy dogs, but further work required verify safety effectiveness this preparation.