Vascular control in humans: focus on the coronary microcirculation.
作者： Yanping Liu , David D. Gutterman
DOI: 10.1007/S00395-009-0775-Y
关键词: Coronary artery disease 、 Myogenic contraction 、 Cardiovascular Physiological Phenomena 、 Perfusion 、 Microcirculation 、 Coronary circulation 、 Internal medicine 、 Disease 、 Vasomotor 、 Medicine 、 Cardiology
摘要: Myocardial perfusion is regulated by a variety of factors that influence arteriolar vasomotor tone. An understanding the physiological and pathophysiological modulate coronary blood flow provides basis for judicious use medications treatment patients with artery disease. Vasomotor properties circulation vary among species. This review highlights results recent studies examine mechanisms which human microcirculation in normal disease states, focusing on diabetes. Multiple pathways responsible myogenic constriction flow-mediated dilation arterioles are addressed. The important role endothelium-derived hyperpolarizing factors, their interactions mediating dilation, as well speculation regarding clinical significance emphasized. Unique vs. other species discussed.
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