Organic impurity profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets seized in The Netherlands.
作者： M.M. van Deursen , E.R.A. Lock , A.J. Poortman-van der Meer
DOI: 10.1016/S1355-0306(06)71588-X
关键词: Mass spectrum 、 Analytical chemistry 、 Repeatability 、 Gas chromatography–mass spectrometry 、 Impurity profiling 、 Chromatography 、 Impurity 、 Reproducibility 、 MDMA 、 Chemistry
摘要: In this study, a new method was developed for the impurity profiling of illicit MDMA tablets. The extraction efficiency, linearity, repeatability and reproducibility were evaluated. Eighty two tablets coming from presumed unrelated large seizures in 2004 (n >500 tablets) analyzed by gas chromatography mass spectrometry (GC-MS) order to assess discrimination power method. latter found be practical, robust, relatively easy perform, highly discriminative yielding good chromatography. addition, some impurities detected identified. Their chemical structures spectra are reported.
elsevier.com
sci-hub.se 参考文章(19)
Wing-Chi Cheng, Nai-Leung Poon, Man-Fai Chan, Chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets seized in Hong Kong. Journal of Forensic Sciences. ,vol. 48, pp. 1249- 1259 ,(2003) , 10.1520/JFS2002426
B. Johnstone, Forensic science review Nature. ,vol. 325, pp. 95- 95 ,(1987) , 10.1038/325095F0
Abdulhameed M. Rashed, Robert A. Anderson, Leslie A. King, Solid-phase extraction for profiling of ecstasy tablets. Journal of Forensic Sciences. ,vol. 45, pp. 413- 417 ,(2000) , 10.1520/JFS14696J
Verweij Am, Impurities in Illicit Drug Preparations: 3,4-(Methylenedioxy)amphetamine and 3,4-(Methylenedioxy)methylamphetamine. Forensic science review. ,vol. 4, pp. 137- 146 ,(1992)
Laura Aalberg, Kjell Andersson, Christina Bertler, Michael D. Cole, Yvonne Finnon, Henk Huizer, Kaisa Jalava, Elisabet Kaa, Eric Lock, Alvaro Lopes, Anneke Poortman-van der Meer, Erkki Sippola, Johan Dahlén, Development of a harmonised method for the profiling of amphetamines : II. Stability of impurities in organic solvents Forensic Science International. ,vol. 149, pp. 231- 241 ,(2005) , 10.1016/J.FORSCIINT.2004.06.019
T. Sitalaximi, R. Trivedi, V. K. Kashyap, Autosomal microsatellite profile of three socially diverse ethnic Tamil populations of India. Journal of Forensic Sciences. ,vol. 48, pp. 1- 2 ,(2003) , 10.1520/JFS2002231
M. Świst, J. Wilamowski, D. Zuba, J. Kochana, A. Parczewski, Determination of synthesis route of 1-(3,4-methylenedioxyphenyl)-2-propanone (MDP-2-P) based on impurity profiles of MDMA. Forensic Science International. ,vol. 149, pp. 181- 192 ,(2005) , 10.1016/J.FORSCIINT.2004.06.016
Dietmar Springer, Giselher Fritschi, Hans H. Maurer, Metabolism and toxicological detection of the new designer drug 3′,4′-methylenedioxy-α-pyrrolidinopropiophenone studied in urine using gas chromatography–mass spectrometry Journal of Chromatography B. ,vol. 793, pp. 331- 342 ,(2003) , 10.1016/S1570-0232(03)00350-7
Fabien Palhol, Sophie Boyer, Norbert Naulet, Martine Chabrillat, Impurity profiling of seized MDMA tablets by capillary gas chromatography Analytical and Bioanalytical Chemistry. ,vol. 374, pp. 274- 281 ,(2002) , 10.1007/S00216-002-1477-6
R.J. Renton, J.S. Cowie, M.C.H. Oon, A study of the precursors, intermediates and reaction by-products in the synthesis of 3,4-methylenedioxymethylamphetamine and its application to forensic drug analysis Forensic Science International. ,vol. 60, pp. 189- 202 ,(1993) , 10.1016/0379-0738(93)90238-6