Reduction of cardiac and pulmonary complication probabilities after breathing adapted radiotherapy for breast cancer

摘要: Purpose: Substantial reductions of cardio-pulmonary radiation doses can be achieved using voluntary deep inspiration breath-hold (DIBH) or free breathing gating (IG) in radiotherapy after conserving surgery for breast cancer. The purpose this study is to evaluate the radiobiological implications such dosimetric benefits. Methods and Materials: Patients from previously reported studies were pooled a total 33 patients. All patients underwent DIBH (FB) scans, 17 an additional IG scan. Tangential conformal treatment plans covering remaining breast, internal mammary, periclavicular nodes optimized each scan, prescription dose 48 Gy. Normal tissue complication probabilities calculated relative seriality model heart, proposed by Burman et al. lung. Results: Previous computed tomography showed that both provided reduction lung V50 (relative volume receiving more than 50% dose) on order 30–40%, 80–90% heart left-sided cancers. Corresponding pneumonitis probability 28.1% (range, 0.7–95.6%) FB could reduced 2.6% 0.1–40.1%) IG, 4.3% 0.1–59%) DIBH. cardiac mortality 4.8% 0.1–23.4%) 0.5% 0.1–2.6%) 0.1% 0–3.0%) Conclusions: Remarkable potential shown simple reduce risk common technique adjuvant tangential irradiation.