The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis.
作者： D Liu , I Evans , G Britton , I Zachary
关键词: Vascular endothelial growth inhibitor 、 Biology 、 Vascular endothelial growth factor C 、 S1PR1 、 Kinase insert domain receptor 、 Vascular endothelial growth factor B 、 Vascular endothelial growth factor 、 Angiogenesis 、 Vascular endothelial growth factor A 、 Cancer research
摘要: Early growth response 3 (Egr3) is a member of zinc-finger transcription factor subfamily, which we previously found to be strongly upregulated by vascular endothelial (VEGF)-A in an oligonucleotide microarray screen cells. Here, show that Egr3 the predominant Egr family VEGF cells at 45 min, and induced rapid increase Egr-dependent transcriptional activation mediated via its major signalling receptor, VEGFR2/KDR, protein kinase C (PKC) pathway. VEGF-induced gene expression was also part PKC-dependent D. Inhibition RNA interference effective inhibiting basal expression, it inhibited VEGF-mediated cell proliferation, migration tubulogenesis. These findings indicate has essential downstream role functions leading angiogenesis may have particular relevance for adult angiogenic processes involved repair neovascular disease.
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