Type I Ribosome-Inactivating Proteins from Saponaria officinalis
作者： Alessio Lombardi , Richard S. Marshall , Carmelinda Savino , Maria Serena Fabbrini , Aldo Ceriotti
DOI: 10.1007/978-3-642-12176-0_4
关键词: Protein subunit 、 Ribosome-inactivating protein 、 Biochemistry 、 Saporin 、 Biology 、 Heterologous 、 Ricin 、 Biosynthesis 、 Gene isoform 、 Saponaria officinalis
摘要: Saporins are ribosome-inactivating proteins (RIPs) extracted from different tissues of the soapwort plant (Saponaria officinalis L.). While biosynthesis these and their roles in planta have received little attention, saporins been extensively used for production targeted toxins therapeutical research applications. The biochemical features one group closely related saporin isoforms, collectively named SO6, characterized considerable detail. In this chapter, we summarize available information on family proteins, including catalytic activity, 3D-structure, biosynthetic intoxication pathway(s), emphasizing differences between members characteristics that distinguish subunit prototype Type II RIP ricin. use heterologous systems saporin-based chimeric is also described.
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