Mucinous and nonmucinous appendiceal adenocarcinomas: different clinicopathological features but similar genetic alterations.
作者： Wareef Kabbani , Patrick S Houlihan , Rajayalaksh Luthra , Stanley R Hamilton , Asif Rashid
DOI: 10.1038/MODPATHOL.3880572
关键词: Appendix 、 Gastroenterology 、 Pseudomyxoma peritonei 、 Microsatellite instability 、 Adenocarcinoma 、 Clinicopathological features 、 Pathology 、 Survival analysis 、 P53 overexpression 、 Medicine 、 Internal medicine 、 Immunohistochemistry
摘要: The genetic alterations of appendiceal carcinomas have not been reported in detail. We studied the clinicopathological factors and including microsatellite instability, p53 overexpression, mutations K-ras proto-oncogene 30 adenocarcinomas, consisting 23 mucinous 7 nonmucinous carcinomas. Sixteen (70%) presented with pseudomyxoma peritonei, but 6 (86%) appendicitis (P =.002). All were stable, overexpression was present only 1 (3%) mutation 11 20 (55%) carcinomas, 8 16 (50%) 3 4 (75%) mean survival patients 26 +/- 19 months compared 13 9 for =.0002). Our findings suggest that appendix similar alterations, different clinical presentation prognosis.
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