Radiation therapy of esophageal cancer : role of high dose rate brachytherapy

摘要: Abstract Fifty untreated cases of squamous cell carcinoma arising from the middle one-third esophagus, with no apparent extraesophageal spread on a computed tomography (CT) scan and Karnofsky performance status over 70, were treated by external beam irradiation to dose 3500 cGy/15 fractions/3 weeks. Twenty-five patients (Group A) received treatment further 2000 cGy/10 fractions/ 2 Another group 25 B) high rate intracavitary 1200 cGy delivered in two sessions 600 each week apart. All assessed symptomatically, endoscopically, radiologically every 3 months. There was marked difference at end 1 year relief dysphagia (37.5% Group A vs. 70.6% B), local control (25% although results statistically insignificant ( p > 0.05) actuarial survival (44% lvs. 78% which was, however, significant (z = 2.83). The cumulative radiation effect (CRE) 1729 reu 1741 reu, but biological better irradiation. Eight percent had strictures contrast 4% alone. Moderate doses can give response than alone for same esophageal carcinoma.